This region of space is said to be intelligent but only those with psionic sensitivity can detect the emmination sof the lifeform known as Cthugha. Psi sensitive individuals who do travel to the region suffer from emotional breakdowns and often commit suicide.
In 2387 the Romulan Cruiser Ch’ka vanished in this region. Their last transmission said “…We have encountered the godhead and are damned…”
On many systems, Cthugha is worshipped as a god. The Cult of the Bloated Lady often perform rituals to Cthugha that involve great bon fires and human sacrifice.